304 citations · 623 across the 11 of their papers we have counts for
12 papers
Quantification of lubrication and particle size distribution effects on tensile strength and stiffness of tablets
Sonia M. Razavi, Marcial Gonzalez, Alberto M. Cuitiño
We adopt a Quality by Design (QbD) paradigm to better control the mechanical properties of tablets. To this end, the effect of particle size distribution, lubricant concentration,…
The effect of mechanical strain on properties of lubricated tablets compacted at different pressures
Pallavi Pawar, Hee Joo, Gerardo Callegari +3
A full factorial design of experiments was used to study the effect of blend shear strain on the compaction process, relative density and strength of pharmaceutical tablets. The po…
Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing
Sonia M. Razavi, Gerardo Callegari, German Drazer +1
An ultrasound measurement system was employed as a non-destructive method to evaluate its reliability in predicting the tensile strength of tablets and investigate the benefits of…
Microstructure evolution of compressible granular systems under large deformations
Marcial Gonzalez, Alberto M. Cuitino
We report three-dimensional particle mechanics static calculations that predict the microstructure evolution during die-compaction of elastic spherical particles up to relative den…
General and mechanistic optimal relationships for tensile strength of doubly convex tablets under diametrical compression
Sonia M. Razavi, Marcial Gonzalez, Alberto M. Cuitino
We propose a general framework for determining optimal relationships for tensile strength of doubly convex tablets under diametrical compression. This approach is based on the obse…
A nonlocal contact formulation for confined granular systems
Marcial Gonzalez, Alberto Cuitino
We present a nonlocal formulation of contact mechanics that accounts for the interplay of deformations due to multiple contact forces acting on a single particle. The analytical fo…
Efficient and robust constitutive integrators for single-crystal plasticity modeling
S. N. Kuchnicki, A. M. Cuitino, R. A. Radovitzky
Simulations of the dynamic deformations of metal samples require elastic-plastic constitutive updates of the material behavior to be performed over a small time step between update…
An Exactly Solvable Phase-Field Theory of Dislocation Dynamics, Strain Hardening and Hysteresis in Ductile Single Crystals
M. Koslowski, A. M. Cuitiño, M. Ortiz
An exactly solvable phase-field theory of dislocation dynamics, strain hardening and hysteresis in ductile single crystals is developed. The theory accounts for: an arbitrary numbe…
Two-phase densification of cohesive granular aggregates
Gustavo Gioia, Alberto M. Cuitino
When poured into a container, cohesive granular materials form low-density, open granular aggregates. If pressed upon with a ram, these aggregates densify by particle rearrangement…
A Multiscale Approach for Modeling Crystalline Solids
A. M. Cuitino, L. Stainier, G. Wang +4
In this paper we present a modeling approach to bridge the atomistic with macroscopic scales in crystalline materials. The methodology combines identification and modeling of the c…
A Micromechanical Model of Hardening, Rate Sensitivity and Thermal Softening in BCC Single Crystals
Laurent Stainier, Alberto M. Cuitino, Michael Ortiz
The present paper is concerned with the development of a micromechanical model of the hardening, rate-sensitivity and thermal softening of bcc crystals. In formulating the model we…
Folding Energetics in Thin-Film Diaphragms
Gustavo Gioia, Antonio DeSimone, Michael Ortiz +1
We perform experiments on thin-film diaphragms to show that the folding patterns of anisotropically compressed diaphragms are strikingly different from those of isotropically compr…