225 citations · 906 across the 32 of their papers we have counts for
10 papers · 1 filter
Folding Rate Optimization Promotes Frustrated Interactions in Entangled Protein Structures
Federico Norbiato, Flavio Seno, Antonio Trovato +1
Many native structures of proteins accomodate complex topological motifs such as knots, lassos, and other geometrical entanglements. How proteins can fold quickly even in the prese…
Exploring the correlation between the folding rates of proteins and the entanglement of their native states
Marco Baiesi, Enzo Orlandini, Flavio Seno +1
The folding of a protein towards its native state is a rather complicated process. However there are empirical evidences that the folding time correlates with the contact order, a…
Bubble-bound state of triple-stranded DNA: Efimov Physics in DNA with repulsion
Jaya Maji, Flavio Seno, Antonio Trovato +1
The presence of a thermodynamic phase of a three-stranded DNA, namely, a mixed phase of bubbles of two bound strands and a single one, is established for large dimensions ($d\geq 5…
Linking in domain-swapped protein dimers
Marco Baiesi, Enzo Orlandini, Antonio Trovato +1
The presence of knots has been observed in a small fraction of single-domain proteins and related to their thermodynamic and kinetic properties. The exchanging of identical structu…
Fibril elongation mechanisms of HET-s prion-forming domain: Topological evidence for growth polarity
Marco Baiesi, Flavio Seno, Antonio Trovato
The prion-forming C-terminal domain of the fungal prion HET-s forms infectious amyloid fibrils at physiological pH. The conformational switch from the non-prion soluble form to the…
When a DNA Triple helix melts: An analog of the Efimov state
Jaya Maji, Somendra M. Bhattacharjee, Flavio Seno +1
The base sequences of DNA contain the genetic code and to decode it a double helical DNA has to open its base pairs. Recent studies have shown that one can use a third strand to id…