3 papers
stat.ME2026
Two-dose vs. Three-Dose Optimization Under Sample Size Constraint
Linda Sun, Yixin Ren, Cong Chen
Dose optimization is a hallmark of Project Optimus for oncology drug development. The number of doses to include in a dose optimization study depends on the totality of evidence, w…
stat.AP2025
Advancing Waterfall Plots for Cancer Treatment Response Assessment through Adjustment of Incomplete Follow-Up Time
Zhe, Wang, Linda Z. Sun +1
Waterfall plots are a key tool in early phase oncology clinical studies for visualizing individual patients' tumor size changes and provide efficacy assessment. However, comparing…
stat.AP2024
Generalized Design of Basket Trials with P-value Combination Test
Heng Zhou, Linda Sun, Fang Liu +1
The oncology exploratory basket trial design with pruning and pooling (P&P) approach has gained increasing popularity in recent years for its simplicity and efficiency. This method…