883 citations · 1k across the 3 of their papers we have counts for
3 papers
Why highly expressed proteins evolve slowly
D. Allan Drummond, Jesse D. Bloom, Christoph Adami +2
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, f…
Inferring interactions from combinatorial protein libraries
Jeffrey B. Endelman, Jesse D. Bloom, Christopher R. Otey +2
Proteins created by combinatorial methods in vitro are an important source of information for understanding sequence-structure-function relationships. Alignments of folded proteins…
Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins
D. Allan Drummond, Brent L. Iverson, George Georgiou +1
Recently, several groups have used error-prone polymerase chain reactions to construct mutant libraries containing up to 27 nucleotide mutations per gene on average, and reported a…