14 papers
Powering RCTs for marginal effects with GLMs using prognostic score adjustment
Emilie Højbjerre-Frandsen, Mark J. van der Laan, Alejandro Schuler
In randomized clinical trials (RCTs), the accurate estimation of marginal treatment effects is crucial for determining the efficacy of interventions. Enhancing the statistical powe…
Experiment-selector cross-validated targeted maximum likelihood estimator for hybrid RCT-external data studies
Lauren Eyler Dang, Jens Magelund Tarp, Trine Julie Abrahamsen +4
Augmenting a randomized controlled trial (RCT) with external data may increase power at the risk of introducing bias. To select and analyze the experiment (RCT alone or combined wi…
Machine learning to optimize precision in the analysis of randomized trials: A journey in pre-specified, yet data-adaptive learning
Laura B. Balzer, Mark J. van der Laan, Maya L. Petersen
Covariate adjustment is an approach to improve the precision of trial analyses by adjusting for baseline variables that are prognostic of the primary endpoint. Motivated by the SEA…
Assessing treatment effects in observational data with missing confounders: A comparative study of practical doubly-robust and traditional missing data methods
Brian D. Williamson, Chloe Krakauer, Eric Johnson +13
In pharmacoepidemiology, safety and effectiveness are frequently evaluated using readily available administrative and electronic health records data. In these settings, detailed co…
Semi-parametric efficient estimation of small genetic effects in large-scale population cohorts
Olivier Labayle, Breeshey Roskams-Hieter, Joshua Slaughter +5
Population genetics seeks to quantify DNA variant associations with traits or diseases, as well as interactions among variants and with environmental factors. Computing millions of…
The impact of job stability on monetary poverty in Italy: causal small area estimation
Katarzyna Reluga, Dehan Kong, Setareh Ranjbar +2
Job stability - encompassing secure contracts, adequate wages, social benefits, and career opportunities - is a critical determinant in reducing monetary poverty, as it provides ho…