4 papers
Long-term evolution of regulatory DNA sequences. Part 2: Theory and future challenges
Elia Mascolo, Réka Borbély, Noa Ottilie Borst +3
Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yi…
Long-term evolution of regulatory DNA sequences. Part 1: Simulations on global, biophysically-realistic genotype-phenotype maps
Elia Mascolo, Réka Borbély, Santiago Herrera-Ãlvarez +3
Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yi…
Meta-Learning Theory-Informed Inductive Biases using Deep Kernel Gaussian Processes
Bahti Zakirov, GaÅ¡per TkaÄik
Normative and task-driven theories offer powerful top-down explanations for biological systems, yet the goals of quantitatively arbitrating between competing theories, and utilizin…
ML-PWS: Estimating the Mutual Information Between Experimental Time Series Using Neural Networks
Manuel Reinhardt, GaÅ¡per TkaÄik, Gašper Tkačik +1
The ability to quantify information transmission is crucial for the analysis and design of both natural and engineered systems. For systems driven by time-varying signals, the fund…