2 papers
q-bio.PE2026
Epigenetic state inheritance drivers drug-tolerant persister-induced resistance in solid tumors: A stochastic agent-based model
Xiyin Liang, Jinzhi Lei
The efficacy of anti-cancer therapies is severely limited by the emergence of drug resistance. While genetic drivers are well-characterized, growing evidence suggests that non-gene…
q-bio.MN2024
A computational scheme connecting gene regulatory network dynamics with heterogeneous stem cell regeneration
Yakun Li, Xiyin Liang, Jinzhi Lei
Stem cell regeneration is a vital biological process in self-renewing tissues, governing development and tissue homeostasis. Gene regulatory network dynamics are pivotal in control…