3 papers
q-bio.BM2026
Disentangling multispecific antibody function with graph neural networks
Joshua Southern, Changpeng Lu, Santrupti Nerli +4
Multispecific antibodies offer transformative therapeutic potential by engaging multiple epitopes simultaneously, yet their efficacy is an emergent property governed by complex mol…
q-bio.BM2025
Tokenizing Loops of Antibodies
Ada Fang, Robert G. Alberstein, Simon Kelow +1
The complementarity-determining regions of antibodies are loop structures that are key to their interactions with antigens, and of high importance to the design of novel biologics.…
q-bio.BM2025
Conformation-Aware Structure Prediction of Antigen-Recognizing Immune Proteins
Frédéric A. Dreyer, Jan Ludwiczak, Karolis Martinkus +8
We introduce Ibex, a pan-immunoglobulin structure prediction model that achieves state-of-the-art accuracy in modeling the variable domains of antibodies, nanobodies, and T-cell re…