27 citations · 134 across the 11 of their papers we have counts for
11 papers
On the relation between native geometry and conformational plasticity
P. F. N. Faisca, C. M. Gomes
In protein folding the term plasticity refers to the number of alternative folding pathways encountered in response to free energy perturbations such as those induced by mutation.…
Identifying critical residues in protein folding: Insights from phi-value and Pfold analysis
P. F. N. Faisca, R. D. M. Travasso, R. C. Ball +1
We apply a simulational proxy of the phi-value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding reactions of two small latt…
Pathways to folding, nucleation events and native geometry
Rui D. M. Travasso, M. M. Telo da Gama, P. F. N. Faisca
We perform extensive Monte Carlo simulations of a lattice model and the Go potential to investigate the existence of folding pathways at the level of contact cluster formation for…
Cooperativity and the origins of rapid, single-exponential kinetics in protein folding
P. F. N. Faisca, K. W. Plaxco
The folding of naturally occurring, single domain proteins is usually well-described as a simple, single exponential process lacking significant trapped states. Here we further exp…
Nucleation phenomena in protein folding: The modulating role of protein sequence
R. D. M. Travasso, P. F. N. Faisca, M. M. Telo da Gama
For the vast majority of naturally occurring, small, single domain proteins folding is often described as a two-state process that lacks detectable intermediates. This observation…
Folding of small proteins: A matter of geometry?
P. F. N. Faisca, M. M. Telo da Gama
We review some of our recent results obtained within the scope of simple lattice models and Monte Carlo simulations that illustrate the role of native geometry in the folding kinet…