6 papers
Compatibility of Missing Data Handling Methods across the Stages of Producing Clinical Prediction Models
Antonia Tsvetanova, Matthew Sperrin, David A. Jenkins +7
Missing data is a challenge when developing, validating and deploying clinical prediction models (CPMs). Traditionally, decisions concerning missing data handling during CPM develo…
A decomposition of Fisher's information to inform sample size for developing or updating fair and precise clinical prediction models -- Part 3: continuous outcomes
Rebecca Whittle, Richard D Riley, Lucinda Archer +4
Clinical prediction models enable healthcare professionals to estimate individual outcomes using patient characteristics. Current sample size guidelines for developing or updating…
Critical Appraisal of Fairness Metrics in Clinical Predictive AI
João Matos, Ben Van Calster, Leo Anthony Celi +6
Predictive artificial intelligence (AI) offers an opportunity to improve clinical practice and patient outcomes, but risks perpetuating biases if fairness is inadequately addressed…
A general sample size framework for developing or updating a clinical prediction model
Richard D Riley, Rebecca Whittle, Mohsen Sadatsafavi +4
Aims: To propose a general sample size framework for developing or updating a clinical prediction model using any statistical or machine learning method, based on drawing samples f…
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- Part 2: time-to-event outcomes
Richard D Riley, Gary S Collins, Lucinda Archer +9
Background: When developing a clinical prediction model using time-to-event data, previous research focuses on the sample size to minimise overfitting and precisely estimate the ov…
A decomposition of Fisher's information to inform sample size for developing fair and precise clinical prediction models -- part 1: binary outcomes
Richard D Riley, Gary S Collins, Rebecca Whittle +11
When developing a clinical prediction model, the sample size of the development dataset is a key consideration. Small sample sizes lead to greater concerns of overfitting, instabil…