Molecular mechanisms, thermodynamics, and dissociation kinetics of knob-hole interactions in fibrin

Olga Kononova, Rustem I. Litvinov, Artem Zhmurov +6

Polymerization of fibrin, the primary structural protein of blood clots and thrombi, occurs through binding of knobs 'A' and 'B' in the central nodule of fibrin monomer to compleme…