2 citations · 6 across the 4 of their papers we have counts for
4 papers
Analysis of a detailed multi-stage model of stochastic gene expression using queueing theory and model reduction
Muhan Ma, Juraj Szavits-Nossan, Abhyudai Singh +1
We introduce a biologically detailed, stochastic model of gene expression describing the multiple rate-limiting steps of transcription, nuclear pre-mRNA processing, nuclear mRNA ex…
Bounds on stationary moments in stochastic chemical kinetics
Khem Raj Ghusinga, Cesar A. Vargas-Garcia, Andrew Lamperski +1
In the stochastic formulation of chemical kinetics, the stationary moments of the population count of species can be described via a set of linear equations. However, except for so…
Moment Closure Approximations in a Genetic Negative Feedback Circuit
Mohammad Soltani, Cesar Vargas, Niraj Kumar +2
Auto-regulation, a process wherein a protein negatively regulates its own production, is a common motif in gene expression networks. Negative feedback in gene expression plays a cr…
Nonspecific transcription factor binding reduces variability in transcription factor and target protein expression
Mohammad Soltani, Pavol Bokes, Zachary Fox +1
Transcription factors (TFs) interact with a multitude of binding sites on DNA and partner proteins inside cells. We investigate how nonspecific binding/unbinding to such decoy bind…