10 papers
Open diffusion MRI and connectivity data for epilepsy and surgery: The IDEAS II release
Peter N. Taylor, Gerard Hall, Jonathan Horsley +7
Epileptic seizures are generated in cerebral networks that propagate ictal and interictal activity. The structure of cerebral networks underpinning epileptic activity can be inferr…
Anti-seizure medication load is not correlated with early termination of seizure spread
Nathan Evans, Sarah J. Gascoigne, Guillermo M. Besne +11
Objective: Anti-seizure medications (ASMs) are the mainstay of treatment for epilepsy, yet their effect on seizure spread is not fully understood. Higher ASM doses have been associ…
Seizure duration is associated with multiple timescales in interictal iEEG band power
Mariella Panagiotopoulou, Gabrielle M. Schroeder, Jess Blickwedel +12
Background Seizure severity can change from one seizure to the next within individual people with epilepsy. It is unclear if and how seizure severity is modulated over longer times…
Brain Morphology Normative modelling platform for abnormality and Centile estimation: Brain MoNoCle
Bethany Little, Nida Alyas, Alexander Surtees +7
Normative models of brain structure estimate the effects of covariates such as age and sex using large samples of healthy controls. These models can then be applied to e.g. smaller…
Dual mechanism of Anti-Seizure Medications in controlling seizure activity
Guillermo M. Besne, Emmanuel Molefi, Sarah J. Gascoigne +12
Background: Anti-seizure medications (ASMs) can reduce seizure duration, but their precise modes of action are unclear. Specifically, it is unknown whether ASMs shorten seizures by…
Combined impact of grey and superficial white matter abnormalities: implications for epilepsy surgery
Csaba Kozma, Jonathan Horsley, Gerard Hall +9
Drug-resistant focal epilepsy is associated with abnormalities in the brain in both grey matter (GM) and superficial white matter (SWM). However, it is unknown if both types of abn…