4 papers
Some Bayesian Perspectives on Clinical Trials
Alexandra Sokolova, Vadim Sokolov, Nick Polson
We examine three landmark clinical trials -- ECMO, CALGB~49907, and I-SPY~2 -- through a unified Bayesian framework connecting prior specification, sequential adaptation, and decis…
Bayesian Dynamic Gamma Models for Route-Level Travel Time Reliability
Vadim Sokolov, Refik Soyer
Route-level travel time reliability requires characterizing the distribution of total travel time across correlated segments -- a problem where existing methods either assume indep…
E-values for Adaptive Clinical Trials: Anytime-Valid Monitoring in Practice
Alexandra Sokolova, Vadim Sokolov
Adaptive clinical trials rely on interim analyses, flexible stopping, and data-dependent design modifications that complicate statistical guarantees when fixed-horizon test statist…
Physics-Informed Diffusion Models for Vehicle Speed Trajectory Generation
Vadim Sokolov, Farnaz Behnia, Dominik Karbowski
Synthetic vehicle speed trajectory generation is essential for evaluating vehicle control algorithms and connected vehicle technologies. Traditional Markov chain approaches suffer…