3 papers
stat.ME2026
Modern Causal Inference Approaches to Improve Power for Subgroup Analysis in Randomized Controlled Trials
Antonio D'Alessandro, Jiyu Kim, Samrachana Adhikari +3
Randomized controlled trials (RCTs) often include subgroup analyses to assess whether treatment effects vary across pre-specified patient populations. However, these analyses frequ…
stat.ME2026
Clarifying identification and estimation of treatment effects in the Sequential Parallel Comparison Design
Benjamin Stockton, Michele Santacatterina, Soutrik Mandal +8
Sequential parallel comparison design (SPCD) clinical trials aim to adjust active treatment effect estimates for placebo response to minimize the impact of placebo responders on th…
stat.ME2024
Identification and estimation of causal effects using non-concurrent controls in platform trials
Michele Santacatterina, Federico Macchiavelli Giron, Xinyi Zhang +1
Platform trials are multi-arm designs that simultaneously evaluate multiple treatments for a single disease within the same overall trial structure. Unlike traditional randomized c…