causal inference 1covariate adjustment 1machine learning 1precision improvement 1randomized trials 1
From the 1 of 2 linked papers with an AI index.
2 papers
stat.ME2026
Towards Best Practices for Covariate Adjustment in Regulatory Trials: From Fixed to Data-Adaptive Approaches
Laura B. Balzer, Lei Nie, Issa J. Dahabreh +15
The paper discusses how to improve precision in randomized clinical trials by using covariate adjustment, comparing traditional fixed parametric methods with flexible data‑adaptive…
stat.ME2026
A CV-TMLE global test approach to improve power in rare disease clinical studies with multiple-component endpoints
Tianyue Zhou, Susan Gruber, Hana Lee +3
Rare disease trials face unique statistical challenges due to limited patient populations and heterogeneous clinical manifestations among patients. Multiple endpoints are often nec…