3 papers
stat.ME2026
Poisson process factorization for mutational signature analysis with genomic covariates
Alessandro Zito, Giovanni Parmigiani, Jeffrey W. Miller
Mutational signatures are powerful summaries of the mutational processes altering the DNA of cancer cells. The usual approach to mutational signature analysis consists of decomposi…
stat.ME2025
Compressive Bayesian non-negative matrix factorization for mutational signatures analysis
Alessandro Zito, Jeffrey W. Miller
Non-negative matrix factorization (NMF) is widely used in many applications for dimensionality reduction. Inferring an appropriate number of factors for NMF is a challenging proble…
stat.ME2024
Improved control of Dirichlet location and scale near the boundary
Catherine Xue, Alessandro Zito, Jeffrey W. Miller
Dirichlet distributions are commonly used for modeling vectors in a probability simplex. When used as a prior or a proposal distribution, it is natural to set the mean of a Dirichl…