2 papers
q-bio.QM2026
A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease
Shih-Huan Huang, Matthew W. Cotton, Tuomas P. J. Knowles +2
A central challenge in modeling neurodegenerative diseases is connecting cellular-level mechanisms to tissue-level pathology, in particular to determine whether pathology is driven…
q-bio.BM2025
A universal phase-plane model for in vivo protein aggregation
Matthew W. Cotton, Alain Goriely, David Klenerman +1
Neurodegenerative diseases are driven by the accumulation of protein aggregates in the brain of affected individuals. The aggregation behaviour in vitro is well understood and driv…