6 papers
Digital defocus aberration interference for automated optical microscopy
Haowen Zhou, Shi Zhao, Yujie Fan +4
Automation in optical microscopy is critical for enabling high-throughput imaging across a wide range of biomedical applications. Among the essential components of automated system…
Digital Modeling of Spatial Pathway Activity from Histology Reveals Tumor Microenvironment Heterogeneity
Ling Liao, Changhuei Yang, Maxim Artyomov +5
Spatial transcriptomics (ST) enables simultaneous mapping of tissue morphology and spatially resolved gene expression, offering unique opportunities to study tumor microenvironment…
Recover Biological Structure from Sparse-View Diffraction Images with Neural Volumetric Prior
Renzhi He, Haowen Zhou, Yubei Chen +1
Volumetric reconstruction of label-free living cells from non-destructive optical microscopic images reveals cellular metabolism in native environments. However, current optical to…
Hybrid-illumination multiplexed Fourier ptychographic microscopy with robust aberration correction
Shi Zhao, Haowen Zhou, Changhuei Yang
Fourier ptychographic microscopy (FPM) is a powerful computational imaging modality that achieves high space-bandwidth product imaging for biomedical samples. However, its adoption…
Analytic Fourier ptychotomography for volumetric refractive index imaging
Zhenyu Dong, Haowen Zhou, Ruizhi Cao +5
Three-dimensional (3D) refractive index (RI) tomography offers label-free, quantitative volumetric imaging but faces limitations due to optical aberrations, limited resolution, and…
Single-shot volumetric fluorescence imaging with neural fields
Oumeng Zhang, Haowen Zhou, Brandon Y. Feng +5
Single-shot volumetric fluorescence (SVF) imaging offers a significant advantage over traditional imaging methods that require scanning across multiple axial planes as it can captu…