activity
20112016
most citedImaging proteins at the truly single-molecule level

119 citations · 513 across the 15 of their papers we have counts for

collaborators

16 papers

cond-mat.mes-hall2016★ 26 cited

Mapping Unoccupied Electronic States of Freestanding Graphene by Angle-Resolved Low-Energy Electron Transmission

Flavio Wicki, Jean-Nicolas Longchamp, Tatiana Latychevskaia +2

We report angle-resolved electron transmission measurements through freestanding graphene sheets in the energy range of 18 to 30 eV above the Fermi level. The measurements are carr…

cond-mat.mes-hall2016★ 26 cited

Direct observation of individual charges and their dynamics on graphene by low-energy electron holography

Tatiana Latychevskaia, Flavio Wicki, Jean-Nicolas Longchamp +2

Visualizing individual charges confined to molecules and observing their dynamics with high spatial resolution is a challenge for advancing various fields in science, ranging from…

physics.bio-ph2015★ 119 cited

Imaging proteins at the truly single-molecule level

Jean-Nicolas Longchamp, Stephan Rauschenbach, Sabine Abb +4

Imaging single proteins has been a long-standing ambition for advancing various fields in natural science, as for instance structural biology, biophysics and molecular nanotechnolo…

physics.ins-det2015

Design and Implementation of a Micron-Sized Electron Column Fabricated by Focused Ion Beam Milling

Flavio Wicki, Jean-Nicolas Longchamp, Conrad Escher +1

We have designed, fabricated and tested a micron-sized electron column with an overall length of about 700 microns comprising two electron lenses; a micro-lens with a minimal bore…

physics.bio-ph2014★ 21 cited

Low-energy electron holographic imaging of individual tobacco mosaic virions

Jean-Nicolas Longchamp, Tatiana Latychevskaia, Conrad Escher +1

Modern structural biology relies on NMR, X-ray crystallography and cryo-electron microscopy for gaining information on biomolecules at nanometer, sub-nanometer or atomic resolution…

physics.atm-clus2014★ 27 cited

Holography and Coherent Diffraction with Low-Energy Electrons: A Route towards Structural Biology at the Single Molecule Level

Tatiana Latychevskaia, Jean-Nicolas Longchamp, Conrad Escher +1

The current state of the art in structural biology is led by NMR, X-ray crystallography and TEM investigations. These powerful tools however all rely on averaging over a large ense…

cond-mat.mes-hall2014

Interfacing Ultraclean Graphene with Solid-State Devices

Jean-Nicolas Longchamp, Conrad Escher, Hans-Werner Fink

Interfacing graphene with solid-state devices and maintaining it free of contamination is a crucial step towards a functioning device, be it a semiconductor structure or any other…

physics.ins-det2013★ 13 cited

On artefact-free reconstruction of low-energy (30-250 eV) electron holograms

Tatiana Latychevskaia, Jean-Nicolas Longchamp, Conrad Escher +1

Low-energy electrons (30-250 eV) have been successfully employed for imaging individual biomolecules. The most simple and elegant design of a low-energy electron microscope for ima…

cond-mat.mtrl-sci2013

Low-energy electron holographic imaging of gold nanorods supported by ultraclean graphene

Jean-Nicolas Longchamp, Conrad Escher, Tatiana Latychevskaia +1

An ideal support for electron microscopy shall be as thin as possible and interact as little as possible with the primary electrons. Since graphene is atomically thin and made up o…

physics.bio-ph2013★ 10 cited

Coherent diffraction and holographic imaging of individual biomolecules using low-energy electrons

Tatiana Latychevskaia, Jean-Nicolas Longchamp, Conrad Escher +1

Modern microscopy techniques are aimed at imaging an individual molecule at atomic resolution. Here we show that low-energy electrons with kinetic energies of 50-250 eV offer a pos…

cond-mat.mtrl-sci2013★ 38 cited

Graphene Unit Cell Imaging by Holographic Coherent Diffraction

Jean-Nicolas Longchamp, Tatiana Latychevskaia, Conrad Escher +1

We have imaged a freestanding graphene sheet of 210 nm in diameter with 2 Angstrom resolution by combining coherent diffraction and holography with low-energy electrons. The entire…

cond-mat.mtrl-sci2012★ 62 cited

Ultra-Clean Freestanding Graphene by Platinum-Metal Catalysis

Jean-Nicolas Longchamp, Conrad Escher, Hans-Werner Fink

While freestanding clean graphene is essential for various applications, existing technologies for removing the polymer layer after transfer of graphene to the desired substrate st…

cond-mat.mes-hall2012★ 51 cited

Low-energy electron transmission imaging of clusters on free-standing graphene

Jean-Nicolas Longchamp, Tatiana Latychevskaia, Conrad Escher +1

We investigated the utility of free-standing graphene as a transparent sample carrier for imaging nanometer-sized objects by means of low-energy electron holography. The sample pre…

physics.bio-ph2012★ 26 cited

Non-destructive imaging of an individual protein

Jean-Nicolas Longchamp, Tatiana Latychevskaia, Conrad Escher +1

The mode of action of proteins is to a large extent given by their ability to adopt different conformations. This is why imaging single biomolecules at atomic resolution is one of…

physics.optics2011★ 76 cited

When holography meets coherent diffraction imaging

Tatiana Latychevskaia, Jean-Nicolas Longchamp, Hans-Werner Fink

Modern imaging techniques at the molecular scale rely on utilizing novel coherent light sources like X-ray free electron lasers for the ultimate goal of visualizing such objects as…

physics.optics2011★ 18 cited

Novel Fourier-domain constraint for fast phase retrieval in coherent diffraction imaging

Tatiana Latychevskaia, Jean-Nicolas Longchamp, Hans-Werner Fink

Coherent diffraction imaging (CDI) for visualizing objects at atomic resolution has been realized as a promising tool for imaging single molecules. Drawbacks of CDI are associated…