4 papers
Time-Varying Hazard Patterns and Co-Mutation Profiles of KRAS G12C and G12D in Real-World NSCLC
Robert Amevor, Dennis Baidoo, Emmanuel Kubuafor
Background: KRAS mutations are the largest oncogenic subset in NSCLC. While KRAS G12C is now targetable, no approved therapies exist for G12D. We examined time-to-next-treatment (T…
Adaptive Weighting for Time-to-Event Continual Reassessment Method: Improving Safety in Phase I Dose-Finding Through Data-Driven Delay Distribution Estimation
Robert Amevor, Emmanuel Kubuafor, Dennis Baidoo
Background: Phase I dose-finding trials increasingly encounter delayed-onset toxicities, especially with immunotherapies and targeted agents. The time-to-event continual reassessme…
Assessing the Influence of Locational Suitability on the Spatial Distribution of Household Wealth in Bernalillo County, NM
Onyedikachi J. Okeke, Uloma E. Nelson, Chukwudi Nwaogu +7
This study applies Multiscale Geographically Weighted Regression (MGWR) to examine the spatial determinants of household wealth in Bernalillo County, New Mexico. The model incorpor…
Integrative Prognostic Modeling of Breast Cancer Survival with Gene Expression and Clinical Data
Robert Amevor, Emmanuel Kubuafor, Dennis Baidoo +3
Background: Accurate survival prediction in breast cancer is essential for patient stratification and personalized therapy. Integrating gene expression data with clinical factors m…