7 papers
Time-Varying Hazard Patterns and Co-Mutation Profiles of KRAS G12C and G12D in Real-World NSCLC
Robert Amevor, Dennis Baidoo, Emmanuel Kubuafor
Background: KRAS mutations are the largest oncogenic subset in NSCLC. While KRAS G12C is now targetable, no approved therapies exist for G12D. We examined time-to-next-treatment (T…
Adaptive Weighting for Time-to-Event Continual Reassessment Method: Improving Safety in Phase I Dose-Finding Through Data-Driven Delay Distribution Estimation
Robert Amevor, Emmanuel Kubuafor, Dennis Baidoo
Background: Phase I dose-finding trials increasingly encounter delayed-onset toxicities, especially with immunotherapies and targeted agents. The time-to-event continual reassessme…
Integrative Prognostic Modeling of Breast Cancer Survival with Gene Expression and Clinical Data
Robert Amevor, Emmanuel Kubuafor, Dennis Baidoo +3
Background: Accurate survival prediction in breast cancer is essential for patient stratification and personalized therapy. Integrating gene expression data with clinical factors m…
Evaluation of Time Series Forecasting Models for Predicting Lung Cancer Mortality Rates in the United States: A Comparison with Altuhaifa (2023) Study
E. Kubuafor, D. Baidoo, O. J. Okeke +3
This paper evaluates the performance of the following time series forecasting models - Simple Exponential Smoothing (SES), Holt's Double Exponential Smoothing (HDES), and Autoregre…
Comparing Malaria Trends in the Comoros Islands: ARIMA Modeling and Retrospective Analysis
D. Baidoo, E. Kubuafor, O. O. Joshua +9
Malaria remains a serious health challenge in the Comoros Islands, despite ongoing control efforts. Past studies have shown reductions in cases due to prevention and treatment meas…
Bayesian Hierarchical Methods for Surveillance of Cervical Dystonia Treatments
D. Baidoo, E. Kubuafor, S. F. Osarfo +5
Cervical dystonia, a debilitating neurological disorder marked by involuntary muscle contractions and chronic pain, presents significant treatment challenges despite advances in bo…