978 citations · 1.1k across the 7 of their papers we have counts for
6 papers · 1 filter
The impact of macroscopic epistasis on long-term evolutionary dynamics
Benjamin H. Good, Michael M. Desai
Genetic interactions can strongly influence the fitness effects of individual mutations, yet the impact of these epistatic interactions on evolutionary dynamics remains poorly unde…
Deleterious passengers in adapting populations
Benjamin H Good, Michael M Desai
Most new mutations are deleterious and are eventually eliminated by natural selection. But in an adapting population, the rapid amplification of beneficial mutations can hinder the…
The Fates of Mutant Lineages and the Distribution of Fitness Effects of Beneficial Mutations in Laboratory Budding Yeast Populations
Evgeni M. Frenkel, Benjamin H. Good, Michael M. Desai
The outcomes of evolution are determined by which mutations occur and fix. In rapidly adapting microbial populations, this process is particularly hard to predict because lineages…
Interference limits resolution of selection pressures from linked neutral diversity
Benjamin H. Good, Aleksandra M. Walczak, Richard A. Neher +1
Pervasive natural selection can strongly influence observed patterns of genetic variation, but these effects remain poorly understood when multiple selected variants segregate in n…
The equivalence between weak and strong purifying selection
Benjamin H Good, Michael M Desai
Weak purifying selection, acting on many linked mutations, may play a major role in shaping patterns of molecular evolution in natural populations. Yet efforts to infer these effec…
Fluctuations in fitness distributions and the effects of weak linked selection on sequence evolution
Benjamin H. Good, Michael M. Desai
Evolutionary dynamics and patterns of molecular evolution are strongly influenced by selection on linked regions of the genome, but our quantitative understanding of these effects…