265 citations · 600 across the 13 of their papers we have counts for
5 papers · 1 filter
Epidemiological and evolutionary analysis of the 2014 Ebola virus outbreak
Marta Łuksza, Trevor Bedford, Michael Lässig
The 2014 epidemic of the Ebola virus is governed by a genetically diverse viral population. In the early Sierra Leone outbreak, a recent study has identified new mutations that gen…
Seasonality in the migration and establishment of H3N2 Influenza lineages with epidemic growth and decline
Daniel Zinder, Trevor Bedford, Edward B. Baskerville +3
Background: Influenza A/H3N2 has been circulating in humans since 1968, causing considerable morbidity and mortality. Although H3N2 incidence is highly seasonal, how such seasonali…
Assessing phenotypic correlation through the multivariate phylogenetic latent liability model
Gabriela B. Cybis, Janet S. Sinsheimer, Trevor Bedford +3
Understanding which phenotypic traits are consistently correlated throughout evolution is a highly pertinent problem in modern evolutionary biology. Here, we propose a multivariate…
Identifying the genetic basis of antigenic change in influenza A(H1N1)
William T. Harvey, Victoria Gregory, Donald J. Benton +7
Determining phenotype from genetic data is a fundamental challenge. Influenza A viruses undergo rapid antigenic drift and identification of emerging antigenic variants is critical…
Quantifying evolutionary constraints on B cell affinity maturation
Connor O. McCoy, Trevor Bedford, Vladimir N. Minin +3
The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain de…