5 papers
A Single Equation Explains Go-or-Grow Dynamics in Cyclic Hypoxia
Gopinath Sadhu, Philip K Maini, Mohit Kumar Jolly
We propose a minimal mathematical framework to describe the go-or-grow dynamics of tumor cells comprising two phenotypically distinct populations. One population is migratory and u…
Unifying Theories in High-Dimensional Biology: Approaches, Challenges and Opportunities
Marianne Bauer, Akshit Goyal, Sidhartha Goyal +19
Across biological subdisciplines, the last decade has seen an explosion of high-dimensional datasets, including datasets for cells, species, immune systems, neurons and behaviour.…
Fractal Geometry and Fractional Calculus for Integrative Morphological Mapping of Breast Cancer Complexity
Abhijeet Das, Ramray Bhat, Mohit Kumar Jolly
Breast cancer exhibits intricate morphological and dynamical heterogeneity across cellular, tissue, and tumor scales, posing challenges to conventional modeling approaches that fai…
Balancing the cellular budget: lessons in metabolism from microbes to cancer
B. Vibishan, Mohit Kumar Jolly, Akshit Goyal
Cancer cells are often seen to prefer glycolytic metabolism over oxidative phosphorylation even in the presence of oxygen-a phenomenon termed the Warburg effect. Despite significan…
GRiNS: A Python Library for Simulating Gene Regulatory Network Dynamics
Pradyumna Harlapur, Harshavardhan B, Mohit Kumar Jolly
The emergent dynamics of complex gene regulatory networks govern various cellular processes. However, understanding these dynamics is challenging due to the difficulty of parameter…