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q-bio.QM2012
Running PeptideProphet Separately on Replicates Improves Peptide Identification Results
Chao Yang, Zengyou He, Weichuan Yu
Limited spectrum coverage is a problem in shotgun proteomics. Replicates are generated to improve the spectrum coverage. When integrating peptide identification results obtained fr…
q-bio.QM2012
A Combinatorial Perspective of the Protein Inference Problem
Chao Yang, Zengyou He, Weichuan Yu
In a shotgun proteomics experiment, proteins are the most biologically meaningful output. The success of proteomics studies depends on the ability to accurately and efficiently ide…