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20242026
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eess.IV2026

Disentangled Multi-modal Learning of Histology and Transcriptomics for Cancer Characterization

Yupei Zhang, Xiaofei Wang, Anran Liu +2

Histopathology remains the gold standard for cancer diagnosis and prognosis. With the advent of transcriptome profiling, multi-modal learning combining transcriptomics with histolo…

eess.IV2025

Cross-modal Diffusion Modelling for Super-resolved Spatial Transcriptomics

Xiaofei Wang, Xingxu Huang, Stephen J. Price +1

The recent advancement of spatial transcriptomics (ST) allows to characterize spatial gene expression within tissue for discovery research. However, current ST platforms suffer fro…

eess.IV2025

Score-based Diffusion Model for Unpaired Virtual Histology Staining

Anran Liu, Xiaofei Wang, Jing Cai +1

Hematoxylin and eosin (H&E) staining visualizes histology but lacks specificity for diagnostic markers. Immunohistochemistry (IHC) staining provides protein-targeted staining but i…

eess.IV2025

Adaptive Spatial Transcriptomics Interpolation via Cross-modal Cross-slice Modeling

NingFeng Que, Xiaofei Wang, Jingjing Chen +2

Spatial transcriptomics (ST) is a promising technique that characterizes the spatial gene profiling patterns within the tissue context. Comprehensive ST analysis depends on consecu…

eess.IV2024

Knowledge-driven Subspace Fusion and Gradient Coordination for Multi-modal Learning

Yupei Zhang, Xiaofei Wang, Fangliangzi Meng +2

Multi-modal learning plays a crucial role in cancer diagnosis and prognosis. Current deep learning based multi-modal approaches are often limited by their abilities to model the co…