43 citations · 206 across the 23 of their papers we have counts for
24 papers
Protein container disassembly pathways depend on geometric design
Q. Roussel, S. Benbedra, R Twarock
The majority of viruses are organised according to the structural blueprints of the seminal Caspar-Klug theory. However, there are a number of notable exceptions to this geometric…
An interaction network approach predicts protein cage architectures in bionanotechnology
Farzad Fatehi, Reidun Twarock
Protein nanoparticles play pivotal roles in many areas of bionanotechnology, including drug delivery, vaccination and diagnostics. These technologies require control over the disti…
An age-structured model of hepatitis B viral infection highlights the potential of different therapeutic strategies
Farzad Fatehi, Richard J. Bingham, Eric C. Dykeman +2
Hepatitis B virus is a global health threat, and its elimination by 2030 has been prioritised by the World Health Organisation. Here we present an age-structured model for the immu…
Therapeutic Interfering Particles Exploiting Viral Replication and Assembly Mechanisms Show Promising Performance: A Modelling Study
Farzad Fatehi, Richard J. Bingham, Pierre-Philippe Dechant +2
Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate in the presence of t…
Comparing antiviral strategies against COVID-19 via multiscale within-host modelling
Farzad Fatehi, Richard J Bingham, Eric C Dykeman +2
Within-host models of COVID-19 infection dynamics enable the merits of different forms of antiviral therapy to be assessed in individual patients. A stochastic agent-based model of…
A multi-scale model of virus pandemic: Heterogeneous interactive entities in a globally connected world
Nicola Bellomo, Richard Bingham, Mark A. J. Chaplain +6
This paper is devoted to the multidisciplinary modelling of a pandemic initiated by an aggressive virus, specifically the so-called \textit{SARS--CoV--2 Severe Acute Respiratory Sy…