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Crucial stages of protein folding through a solvable model: predicting target sites for enzyme-inhibiting drugs
Cristian Micheletti, Fabio Cecconi, Alessandro Flammini +1
An exactly solvable model based on the topology of a protein native state is applied to identify bottlenecks and key-sites for the folding of HIV-1 Protease. The predicted sites ar…
Elastic properties of proteins: insight on the folding process and evolutionary selection of native structures
Cristian Micheletti, Gianluca Lattanzi, Amos Maritan
We carry out a theoretical study of the vibrational and relaxation properties of naturally-occurring proteins with the purpose of characterizing both the folding and equilibrium th…
Optimal prediction of folding rates and transition state placement from native state geometry
Cristian Micheletti
A variety of experimental and theoretical studies have established that the folding process of monomeric proteins is strongly influenced by the topology of the native state. In par…