4 papers
Robust Power and Sample Size Calculations in Quasi-likelihood Models: Methods and Practice
Shijie Yuan, Amy Cochran, Paul Rathouz
Accurate power and sample size (PSS) calculations are essential for designing studies that use quasi-likelihood (QL) models, which extend generalized linear models (GLMs) to settin…
Monitoring Adverse Events Through Bayesian Nonparametric Clustering Across Studies
Shijie Yuan, Kevin Roberts, Noirrit Kiran Chandra +3
We introduce a Bayesian nonparametric inference approach for aggregate adverse event (AE) monitoring across studies. The proposed model seamlessly integrates external data from his…
SIMBA -- A Bayesian Decision Framework for the Identification of Optimal Biomarker Subgroups for Cancer Basket Clinical Trials
Shijie Yuan, Jiaxin Liu, Zhihua Gong +5
We consider basket trials in which a biomarker-targeting drug may be efficacious for patients across different disease indications. Patients are enrolled if their cells exhibit som…
The Modified Combo i3+3 Design for Novel-Novel Combination Dose-Finding Trials in Oncology
Jiaxin Liu, Shijie Yuan, Qiqi Deng +1
We consider a modified Ci3+3 (MCi3+3) design for dual-agent dose-finding trials in which both agents are tested on multiple doses. This usually happens when the agents are novel th…