activity
20102022
most citedIs the general time-reversible model bad for molecular phylogenetics?

71 citations · 115 across the 14 of their papers we have counts for

collaborators

15 papers

q-bio.PE2022

Evaluation of the relative performance of the subflattenings method for phylogenetic inference

Joshua Stevenson, Barbara Holland, Michael Charleston +1

The algebraic properties of flattenings and subflattenings provide direct methods for identifying edges in the true phylogeny -- and by extension the complete tree -- using pattern…

q-bio.PE2021

The Shape of Phylogenies Under Phase-Type Distributed Times to Speciation and Extinction

Albert Ch. Soewongsono, Barbara R. Holland, Małgorzata M. O'Reilly

Phylogenetic trees are widely used to understand the evolutionary history of organisms. Tree shapes provide information about macroevolutionary processes. However, macroevolutionar…

q-bio.PE2019★ 18 cited

The ancient Operational Code is embedded in the amino acid substitution matrix and aaRS phylogenies

Julia A. Shore, Barbara R. Holland, Jeremy G. Sumner +2

The underlying structure of the canonical amino acid substitution matrix (aaSM) is examined by considering stepwise improvements in the differential recognition of amino acids acco…

q-bio.PE2018

The impracticalities of multiplicatively-closed codon models: a retreat to linear alternatives

Julia A. Shore, Jeremy G. Sumner, Barbara R. Holland

A matrix Lie algebra is a linear space of matrices closed under the operation . The "Lie closure" of a set of matrices is the smallest matrix Lie algebra which co…

q-bio.PE2017★ 5 cited

Exploring the consequences of lack of closure in codon models

Michael D. Woodhams, Jeremy G. Sumner, David A. Liberles +2

Models of codon evolution are commonly used to identify positive selection. Positive selection is typically a heterogeneous process, i.e., it acts on some branches of the evolution…

q-bio.PE2017

Distinguishing between convergent evolution and violation of the molecular clock

Jonathan D. Mitchell, Jeremy G. Sumner, Barbara R. Holland

We give a non-technical introduction to convergence-divergence models, a new modeling approach for phylogenetic data that allows for the usual divergence of species post speciation…

q-bio.QM2016

Developing a statistically powerful measure for quartet tree inference using phylogenetic identities and Markov invariants

Jeremy G Sumner, Amelia Taylor, Barbara R Holland +1

Recently there has been renewed interest in phylogenetic inference methods based on phylogenetic invariants, alongside the related Markov invariants. Broadly speaking, both these a…

astro-ph.IM2016★ 3 cited

Comparison of three Statistical Classification Techniques for Maser Identification

Ellen M. Manning, Barbara R. Holland, Simon P. Ellingsen +3

We applied three statistical classification techniques - linear discriminant analysis (LDA), logistic regression and random forests - to three astronomical datasets associated with…

q-bio.PE2016

Maximum likelihood estimates of pairwise rearrangement distances

Stuart Serdoz, Attila Egri-Nagy, Jeremy Sumner +4

Accurate estimation of evolutionary distances between taxa is important for many phylogenetic reconstruction methods. In the case of bacteria, distances can be estimated using a ra…

stat.AP2014★ 4 cited

Estimating the relative rate of recombination to mutation in bacteria from single-locus variants using composite likelihood methods

Paul Fearnhead, Shoukai Yu, Patrick Biggs +2

A number of studies have suggested using comparisons between DNA sequences of closely related bacterial isolates to estimate the relative rate of recombination to mutation for that…

q-bio.PE2012

A tensorial approach to the inversion of group-based phylogenetic models

Jeremy G. Sumner, Peter D. Jarvis, Barbara R. Holland

Using a tensorial approach, we show how to construct a one-one correspondence between pattern probabilities and edge parameters for any group-based model. This is a generalisation…

q-bio.QM2012

Low-parameter phylogenetic estimation under the general Markov model

Barbara R. Holland, Peter D. Jarvis, Jeremy G. Sumner

In their 2008 and 2009 papers, Sumner and colleagues introduced the "squangles" - a small set of Markov invariants for phylogenetic quartets. The squangles are consistent with the…

q-bio.QM2012★ 1 cited

Novel Distances for Dollo Data

Michael Woodhams, Dorothy A. Steane, Rebecca C. Jones +3

We investigate distances on binary (presence/absence) data in the context of a Dollo process, where a trait can only arise once on a phylogenetic tree but may be lost many times. W…

q-bio.PE2011★ 71 cited

Is the general time-reversible model bad for molecular phylogenetics?

Jeremy Sumner, Peter Jarvis, Jesus Fernandez-Sanchez +3

The general time reversible model (GTR) is presently the most popular model used in phylogentic studies. However, GTR has an undesirable mathematical property that is potentially o…

q-bio.PE2010★ 13 cited

The algebra of the general Markov model on phylogenetic trees and networks

J. G. Sumner, B. H. Holland, P. D. Jarvis

It is known that the Kimura 3ST model of sequence evolution on phylogenetic trees can be extended quite naturally to arbitrary split systems. However, this extension relies heavily…