261 citations · 275 across the 3 of their papers we have counts for
3 papers
Assembling large, complex environmental metagenomes
Adina Chuang Howe, Janet Jansson, Stephanie A. Malfatti +3
The large volumes of sequencing data required to sample complex environments deeply pose new challenges to sequence analysis approaches. De novo metagenomic assembly effectively re…
Illumina Sequencing Artifacts Revealed by Connectivity Analysis of Metagenomic Datasets
Adina Chuang Howe, Jason Pell, Rosangela Canino-Koning +5
Sequencing errors and biases in metagenomic datasets affect coverage-based assemblies and are often ignored during analysis. Here, we analyze read connectivity in metagenomes and i…
Scaling metagenome sequence assembly with probabilistic de Bruijn graphs
Jason Pell, Arend Hintze, Rosangela Canino-Koning +3
Deep sequencing has enabled the investigation of a wide range of environmental microbial ecosystems, but the high memory requirements for {\em de novo} assembly of short-read shotg…