261 citations · 635 across the 5 of their papers we have counts for
3 papers · 1 filter
Assembling large, complex environmental metagenomes
Adina Chuang Howe, Janet Jansson, Stephanie A. Malfatti +3
The large volumes of sequencing data required to sample complex environments deeply pose new challenges to sequence analysis approaches. De novo metagenomic assembly effectively re…
Illumina Sequencing Artifacts Revealed by Connectivity Analysis of Metagenomic Datasets
Adina Chuang Howe, Jason Pell, Rosangela Canino-Koning +5
Sequencing errors and biases in metagenomic datasets affect coverage-based assemblies and are often ignored during analysis. Here, we analyze read connectivity in metagenomes and i…
A Reference-Free Algorithm for Computational Normalization of Shotgun Sequencing Data
C. Titus Brown, Adina Howe, Qingpeng Zhang +2
Deep shotgun sequencing and analysis of genomes, transcriptomes, amplified single-cell genomes, and metagenomes has enabled investigation of a wide range of organisms and ecosystem…