110 citations · 343 across the 11 of their papers we have counts for
7 papers · 1 filter
Simulating Organogenesis in COMSOL: Cell-based Signaling Models
Jannik Vollmer, Denis Menshykau, Dagmar Iber
Most models of biological pattern formation are simulated on continuous domains even though cells are discrete objects that provide internal boundaries to the diffusion of regulato…
Simulating Organogenesis in COMSOL: Parameter Optimization for PDE-based models
Denis Menshykau, Srivathsan Adivarahan, Philipp Germann +2
Morphogenesis is a tightly regulated process that has been studied for decades. We are developing data-based and image-basd mechanistic models for a range of developmental processe…
The Control of Branching Morphogenesis
Dagmar Iber, Denis Menshykau
Many organs of higher organisms are heavily branched structures and arise by an at first sight similar process of branching morphogenesis. Yet the regulatory components and local i…
Dynamic Image-Based Modelling of Kidney Branching Morphogenesis
Srivathsan Adivarahan, Denis Menshykau, Odysse Michos +1
Kidney branching morphogenesis has been studied extensively, but the mechanism that defines the branch points is still elusive. Here we obtained a 2D movie of kidney branching morp…
Kidney branching morphogenesis under the control of a ligand-receptor based Turing mechanism
Denis Menshykau, Dagmar Iber
The main signalling proteins that control early kidney branching have been defined. Yet the underlying mechanism is still elusive. We have previously shown that a Schnakenberg-type…
Simulating Tissue Morphogenesis and Signaling
Dagmar Iber, Simon Tanaka, Patrick Fried +2
During embryonic development tissue morphogenesis and signaling are tightly coupled. It is therefore important to simulate both tissue morphogenesis and signaling simultaneously in…
Digit patterning during limb development as a result of the BMP-receptor interaction
Amarendra Badugu, Conradin Kraemer, Philipp Germann +2
Turing models have been proposed to explain the emergence of digits during limb development. However, so far the molecular components that would give rise to Turing patterns are el…