108 citations · 414 across the 24 of their papers we have counts for
7 papers · 1 filter
Profiling of FSHR Negative Allosteric Modulators on LH/CGR Reveals Biased Antagonism with Implications in Steroidogenesis
Mohammed Akli Ayoub, Romain Yvinec, Gwenhaël Jégot +5
Biased signaling has recently emerged as an interesting mean to modulate the function of many G protein-coupled receptors (GPCRs). Previous studies reported two negative allosteric…
Advances in computational modeling approaches in pituitary gonadotropin signaling
Romain Yvinec, Pascale Crépieux, Eric Reiter +2
Pituitary gonadotropins play an essential and pivotal role in the control of human and animal reproduction within the hypothalamic-pituitary-gonadal (HPG) axis. The computational m…
Follicle-stimulating hormone receptor: Advances and remaining challenges
Francesco De Pascali, Aurélie Tréfier, Flavie Landomiel +6
Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of…
Human Luteinizing Hormone and Chorionic Gonadotropin Display Biased Agonism at the LH and LH/CG Receptors
Laura Riccetti, Romain Yvinec, Danièle Klett +6
Human luteinizing hormone (LH) and chorionic gonadotropin (hCG) have been considered biologically equivalent because of their structural similarities and their binding to the same…
Computational modeling approaches in gonadotropin signaling
Mohammed Akli Ayoub, Romain Yvinec, Pascale Crépieux +1
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) play essential roles in animal reproduction. They exert their function through binding to their cognate receptors, w…
Workflow description to dynamically model β-arrestin signaling networks
Romain Yvinec, Mohammed Akli Ayoub, Francesco De Pascali +3
Dynamic models of signaling networks allow the formulation of hypotheses on the topology and kinetic rate laws characterizing a given molecular network, in-depth exploration and co…
Molecular Distributions in Gene Regulatory Dynamics
Michael C. Mackey, Marta Tyran-Kamińska, Romain Yvinec
We show how one may analytically compute the stationary density of the distribution of molecular constituents in populations of cells in the presence of noise arising from either b…