97 citations · 250 across the 15 of their papers we have counts for
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The Influence of Spatial Variation in Chromatin Density Determined by X-ray Tomograms on the Time to Find DNA Binding Sites
Samuel A. Isaacson, Carolyn A. Larabell, Mark A. Le Gros +2
In this work we examine how volume exclusion caused by regions of high chromatin density might influence the time required for proteins to find specific DNA binding sites. The spat…
Uniform asymptotic approximation of diffusion to a small target
Samuel A. Isaacson, Jay Newby
The problem of the time required for a diffusing molecule, within a large bounded domain, to first locate a small target is prevalent in biological modeling. Here we study this pro…
A First-Passage Kinetic Monte Carlo Method for Reaction-Drift-Diffusion Processes
Ava J. Mauro, Jon Karl Sigurdsson, Justin Shrake +2
Stochastic reaction-diffusion models are now a popular tool for studying physical systems in which both the explicit diffusion of molecules and noise in the chemical reaction proce…
A Comparison of Bimolecular Reaction Models for Stochastic Reaction Diffusion Systems
Ikemefuna C. Agbanusi, Samuel A. Isaacson
Stochastic reaction-diffusion models have become an important tool in studying how both noise in the chemical reaction process and the spatial movement of molecules influences the…