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stat.ME2026
Unbiased estimation in two-stage adaptive enrichment designs
Enyu Li, Nigel Stallard, Ekkehard Glimm +1
Recent advances in biomedical research have identified an increasing number of biomarkers associated with heterogeneity in patient responses to medical treatments. When a treatment…
stat.ME2026
Confidence intervals for two-stage adaptive designs with subpopulation selection
Enyu Li, Nigel Stallard, Ekkehard Glimm +2
We consider clinical trials in which an experimental treatment is compared with a control in pre-specified patient subpopulations. In such settings, adaptive enrichment designs all…