2.4k citations · 11.4k across the 104 of their papers we have counts for
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Transcription-dependent spatial organization of a gene locus
Lev Barinov, Sergey Ryabichko, William Bialek +1
There is growing appreciation that gene function is connected to the dynamic structure of the chromosome. Here we explore the interplay between three-dimensional structure and tran…
Trading bits in the readout from a genetic network
Marianne Bauer, Mariela D. Petkova, Thomas Gregor +2
In genetic networks, information of relevance to the organism is represented by the concentrations of transcription factor molecules. In order to extract this information the cell…
Exploring a strongly non-Markovian animal behavior
Vasyl Alba, Gordon J. Berman, William Bialek +1
A freely walking fly visits roughly 100 stereotyped states in a strongly non-Markovian sequence. To explore these dynamics, we develop a generalization of the information bottlenec…
Searching for sequence features that control DNA flexibility
Yaojun Zhang, Aakash Basu, Taekjip Ha +1
Modern genomics experiments measure functional behaviors for many thousands of DNA sequences. We suggest that, especially when these sequences are chosen at random, it is natural t…
What do we mean by the dimensionality of behavior?
William Bialek
There is growing effort in the "physics of behavior" that aims at complete quantitative characterization of animal movements under more complex, naturalistic conditions. One reacti…
What makes it possible to learn probability distributions in the natural world?
William Bialek, Stephanie E. Palmer, David J. Schwab
Organisms and algorithms learn probability distributions from previous observations, either over evolutionary time or on the fly. In the absence of regularities, estimating the und…