2.4k citations · 11.4k across the 104 of their papers we have counts for
26 papers · 1 filter
Deriving a genetic regulatory network from an optimization principle
Thomas R Sokolowski, Thomas Gregor, William Bialek +1
Many biological systems approach physical limits to their performance, motivating the idea that their behavior and underlying mechanisms could be determined by such optimality. Nev…
How accurately must cells measure the concentrations of signaling molecules?
Marianne Bauer, William Bialek
Information of relevance to the organism often is represented by the concentrations of particular molecules inside a cell. As outside observers we can now measure these concentrati…
Successes and failures of simple statistical physics models for a network of real neurons
Leenoy Meshulam, Jeffrey L. Gauthier, Carlos D. Brody +2
Biological networks exhibit complex, coordinated patterns of activity. Can these patterns be captured precisely in simple models? Here we use measurements of simultaneous activity…
Searching for sequence features that control DNA flexibility
Yaojun Zhang, Aakash Basu, Taekjip Ha +1
Modern genomics experiments measure functional behaviors for many thousands of DNA sequences. We suggest that, especially when these sequences are chosen at random, it is natural t…
Searching for long time scales without fine tuning
Xiaowen Chen, William Bialek
Most of animal and human behavior occurs on time scales much longer than the response times of individual neurons. In many cases, it is plausible that these long time scales emerge…
Coarse--graining and hints of scaling in a population of 1000+ neurons
Leenoy Meshulam, Jeffrey L. Gauthier, Carlos D. Brody +2
In many systems we can describe emergent macroscopic behaviors, quantitatively, using models that are much simpler than the underlying microscopic interactions; we understand the s…