4 papers
Chaotic waves serve as universal pattern generators
Sergey A. Vakulenko, Ivan Sudakow, John Reinitz +1
Excitable media are prevalent models for describing physical, chemical, and biological systems which support wave propagation. In this letter, we show that the time evolution of th…
Biological implications of symmetry in exact solutions for a self-repressing gene
Alexandre F. Ramos, John Reinitz
We chemically characterize the symmetries underlying the exact solutions of a stochastic negatively self-regulating gene. The breaking of symmetry at low molecular number causes th…
Gene networks accelerate evolution by fitness landscape learning
John Reinitz, Sergey Vakulenko, Dmitri Grigoriev +1
We consider evolution of a large population, where fitness of each organism is defined by many phenotypical traits. These traits result from expression of many genes. We propose a…
Noise reduction by coupling of stochastic processes and canalization in biology
Alexandre F. Ramos, Jose Eduardo M. Hornos, John Reinitz
Randomness is an unavoidable feature of the intracellular environment due to chemical reactants being present in low copy number. That phenomenon, predicted by Delbrück long ago \c…