4 papers
Mathematical model of tumor-macrophage interactions: Elucidating the tumor-driven macrophage phenotype reprogramming
Haifeng Zhang, Yipu Qu, Wuyue Yang +1
The interplay between tumor cells and macrophages plays a central regulatory role in cancer progression. In this study, we developed a mathematical model that incorporates tumor ce…
Combination therapy for colorectal cancer with anti-PD-L1 and cancer vaccine: A multiscale mathematical model of tumor-immune interactions
Chenghang Li, Haifeng Zhang, Xiulan Lai +1
The tumor-immune system plays a critical role in colorectal cancer progression. Recent preclinical and clinical studies showed that combination therapy with anti-PD-L1 and cancer v…
Conditional Success of Adaptive Therapy: The Role of Treatment-Holiday Thresholds and Non-Existence of Optimal Strategies Revealed by Mathematical Modelling and Optimal Control
Lanfei Sun, Haifeng Zhang, Kai Kang +5
Adaptive therapy improves cancer treatment by controlling the competition between sensitive and resistant cells through treatment holidays. This study highlights the critical role…
A tumor-immune model of chronic myeloid leukemia with optimal immunotherapeutic protocols
Haifeng Zhang, Changjing Zhuge, Jinzhi Lei
The interactions between tumor cells and the immune system play a crucial role in cancer evolution. In this study, we explore how these interactions influence cancer progression by…