activity
20132026
most citedPrincipal manifold estimation via model complexity selection

6 citations · 15 across the 13 of their papers we have counts for

collaborators

15 papers

stat.ME2026

Causal Inference for Unobservable Multivariate Outcomes, with Applications to Brain Effective Connectivity

Haiyue Song, Ani Eloyan, Youjin Lee

Evaluating the causal effect of an intervention on multivariate outcomes is challenging when the outcomes are interdependent and derived rather than directly observed. Effective co…

q-bio.TO2025

TRAECR: A Tool for Preprocessing Positron Emission Tomography Imaging for Statistical Modeling

Akhil Ambekar, Robert Zielinski, Ani Eloyan

Positron emission tomography (PET) imaging is widely used in a number of clinical applications, including cancer and Alzheimer's disease (AD) diagnosis, monitoring of disease devel…

stat.AP2025

Geometric Modeling of Hippocampal Tau Deposition: A Surface-Based Framework for Covariate Analysis and Off-Target Contamination Detection

Liangkang Wang, Akhil Ambekar, Ani Eloyan

We introduce a framework combining geometric modeling with disease progression analysis to investigate tau deposition in Alzheimer's disease (AD) using positron emission tomography…

stat.AP2024

Longitudinal Principal Manifold Estimation

Robert Zielinski, Kun Meng, Ani Eloyan

Longitudinal magnetic resonance imaging data is used to model trajectories of change in brain regions of interest to identify areas susceptible to atrophy in those with neurodegene…

stat.AP2023

Leveraging population information in brain connectivity via Bayesian ICA with a novel informative prior for correlation matrices

Amanda Mejia, David Bolin, Daniel Spencer +1

Brain functional connectivity (FC), the temporal synchrony between brain networks, is essential to understand the functional organization of the brain and to identify changes due t…

stat.ME2023★ 1 cited

Statistical Inference on Grayscale Images via the Euler-Radon Transform

Kun Meng, Mattie Ji, Jinyu Wang +4

Tools from topological data analysis have been widely used to represent binary images in many scientific applications. Methods that aim to represent grayscale images (i.e., where p…

stat.ME2023

Distributed model building and recursive integration for big spatial data modeling

Emily C. Hector, Brian J. Reich, Ani Eloyan

Motivated by the need for computationally tractable spatial methods in neuroimaging studies, we develop a distributed and integrated framework for estimation and inference of Gauss…

stat.ME2022★ 5 cited

Randomness of Shapes and Statistical Inference on Shapes via the Smooth Euler Characteristic Transform

Kun Meng, Jinyu Wang, Lorin Crawford +1

In this article, we establish the mathematical foundations for modeling the randomness of shapes and conducting statistical inference on shapes using the smooth Euler characteristi…

stat.AP2021

Brain Functional Connectivity Estimation Utilizing Diffusion Kernels on a Structural Connectivity Graph

Nathan Tung, Jerome Sanes, Eli Upfal +1

Functional connectivity (FC) refers to the investigation of interactions between brain regions to understand integration of neural activity in several regions. FC is often estimate…

stat.ML2021

Considerations Across Three Cultures: Parametric Regressions, Interpretable Algorithms, and Complex Algorithms

Ani Eloyan, Sherri Rose

We consider an extension of Leo Breiman's thesis from "Statistical Modeling: The Two Cultures" to include a bifurcation of algorithmic modeling, focusing on parametric regressions,…

stat.AP2021★ 2 cited

Population-level Task-evoked Functional Connectivity via Fourier Analysis

Kun Meng, Ani Eloyan

Functional magnetic resonance imaging (fMRI) is a non-invasive and in-vivo imaging technique essential for measuring brain activity. Functional connectivity is used to study associ…

stat.ME2017★ 6 cited

Principal manifold estimation via model complexity selection

Kun Meng, Ani Eloyan

We propose a framework of principal manifolds to model high-dimensional data. This framework is based on Sobolev spaces and designed to model data of any intrinsic dimension. It in…

stat.AP2015★ 1 cited

Relating multi-sequence longitudinal intensity profiles and clinical covariates in new multiple sclerosis lesions

Elizabeth M. Sweeney, Russell T. Shinohara, Blake E. Dewey +5

Structural magnetic resonance imaging (MRI) can be used to detect lesions in the brains of multiple sclerosis (MS) patients. The formation of these lesions is a complex process inv…

stat.ME2015

PCA leverage: outlier detection for high-dimensional functional magnetic resonance imaging data

Amanda F. Mejia, Mary Beth Nebel, Ani Eloyan +2

Outlier detection for high-dimensional (HD) data is a popular topic in modern statistical research. However, one source of HD data that has received relatively little attention is…

stat.AP2013

Homotopic Group ICA for Multi-Subject Brain Imaging Data

Juemin Yang, Ani Eloyan, Anita Barber +5

Independent Component Analysis (ICA) is a computational technique for revealing latent factors that underlie sets of measurements or signals. It has become a standard technique in…