3 papers
stat.ME2013
Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts
M. Silver, P. Chen, L. Ruoying +5
Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways ana…
stat.AP2012
Identification of gene pathways implicated in Alzheimer's disease using longitudinal imaging phenotypes with sparse regression
Matt Silver, Eva Janousova, Xue Hua +2
We present a new method for the detection of gene pathways associated with a multivariate quantitative trait, and use it to identify causal pathways associated with an imaging endo…
stat.ME2012
Fast Identification of Biological Pathways Associated with a Quantitative Trait Using Group Lasso with Overlaps
Matt Silver, Giovanni Montana
Where causal SNPs (single nucleotide polymorphisms) tend to accumulate within biological pathways, the incorporation of prior pathways information into a statistical model is expec…