67 citations · 73 across the 4 of their papers we have counts for
5 papers · 1 filter
Does Antibiotic Resistance Evolve in Hospitals?
Anna Seigal, Portia Mira, Bernd Sturmfels +1
Nosocomial outbreaks of bacteria are well-documented. Based on these incidents, and the heavy usage of antibiotics in hospitals, it has been assumed that antibiotic resistance evol…
Rational Design of Antibiotic Treatment Plans
Portia M. Mira, Kristina Crona, Devin Greene +3
The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiot…
Evolutionary Predictability and Complications with Additivity
Kristina Crona, Devin Greene, Miriam Barlow
Adaptation is a central topic in theoretical biology, of practical importance for analyzing drug resistance mutations. Several authors have used arguments based on extreme value th…
Antibiotic resistance landscapes: a quantification of theory-data incompatibility for fitness landscapes
Kristina Crona, Dayonna Patterson, Kelly Stack +6
Fitness landscapes are central in analyzing evolution, in particular for drug resistance mutations for bacteria and virus. We show that the fitness landscapes associated with antib…
Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes
Christiane P. Goulart, Mentar Mahmudi, Kristina A. Crona +5
The evolution of antibiotic resistance among bacteria threatens our continued ability to treat infectious diseases. The need for sustainable strategies to cure bacterial infections…