5 papers · 1 filter
Sparse probabilistic evaluation for treatment planning: a feasibility study in IMPT head & neck patients
Jenneke I. de Jong, Steven J. M. Habraken, Albin Fredriksson +4
Probabilistic evaluation improves the trade-off between target coverage and OAR sparing in IMPT but remains computationally demanding. This study proposes sparse probabilistic eval…
Partitioning of multiple brain metastases improves dose gradients in single-isocenter radiosurgery
Johan Sundström, Anton Finnson, Elin Hynning +2
Background: A growing number of cancer patients with brain metastases can benefit from stereotactic radiosurgery (SRS) thanks to recent advances in systemic therapies. With an incr…
Dosimetric impact of real-time re-optimization of proton pencil-beam scanning for moving targets
Ivar Bengtsson, Anders Forsgren, Albin Fredriksson
When treating moving tumors, the precise delivery of proton therapy by pencil beam scanning (PBS) is challenged by the interplay effect. Although several 4D-optimization methods ha…
Interplay-robust optimization for treating irregularly breathing lung patients with pencil beam scanning
Ivar Bengtsson, Anders Forsgren, Albin Fredriksson +1
The steep dose gradients obtained with pencil beam scanning allow for precise tumor targeting at the cost of high sensitivity to uncertainties. Robust optimization is commonly appl…
Fast Spot Order Optimization to Increase Dose Rates in Scanned Particle Therapy FLASH Treatments
Viktor Wase, Oscar Widenfalk, Rasmus Nilsson +2
The advent of ultra-high dose rate irradiation, known as FLASH radiation therapy, has shown promising potential in reducing toxicity while maintaining tumor control. However, the c…