3 papers
q-bio.BM2026
Sampling-based Continuous Optimization for Messenger RNA Design
Feipeng Yue, Ning Dai, Wei Yu Tang +3
Designing messenger RNA (mRNA) sequences for a fixed target protein requires searching an exponentially large synonymous space while optimizing properties that affect stability and…
cs.DS2025
Scalable and Interpretable Identification of Minimal Undesignable RNA Structure Motifs with Rotational Invariance
Tianshuo Zhou, Wei Yu Tang, Apoorv Malik +2
RNA design aims to find a sequence that folds with highest probability into a designated target structure. However, certain structures are undesignable, meaning no sequence can fol…
q-bio.BM2024
Sampling-based Continuous Optimization with Coupled Variables for RNA Design
Wei Yu Tang, Ning Dai, Tianshuo Zhou +2
The task of RNA design given a target structure aims to find a sequence that can fold into that structure. It is a computationally hard problem where some version(s) have been prov…