3 papers
cs.LG2026
Response Magnitude as a Dominant Signal for Held-Out CRISPRi Perturbation Effect Prediction
Mehrdad Shoeibi, Niloofar Yousefi
Predicting the magnitude of a CRISPRi perturbation's transcriptomic effect on held-out target genes is an important open problem in single-cell biology. Recent work has documented…
cs.LG2026
Learning Stable Predictors from Weak Supervision under Distribution Shift
Mehrdad Shoeibi, Elias Hossain, Ivan Garibay +1
Learning from weak, proxy, or relative supervision is common when ground-truth labels are unavailable, but robustness under distribution shift remains poorly understood because the…
q-bio.QM2026
BIOGEN: Evidence-Grounded Multi-Agent Reasoning Framework for Transcriptomic Interpretation in Antimicrobial Resistance
Elias Hossain, Mehrdad Shoeibi, Ivan Garibay +1
Interpreting gene clusters from RNA sequencing (RNA-seq) remains challenging, especially in antimicrobial resistance studies where mechanistic insight is important for hypothesis g…