5 papers
Effects of Rim Fluctuations in Classical Nucleation Theory of Virus Capsids
Alexander Bryan Clark, Paul van der Schoot, Henri Orland +1
Most spherical viruses exhibit icosahedral symmetry, yet the growth of viral shells remains poorly understood due to the short lifetimes and broad size distribution of assembly int…
Thermodynamic stability and kinetic control of capsid morphologies in hepatitis B virus
Kevin Yang, Juana Martin Gonzalez, Alireza Ramezani +2
Polymorphism has been observed in viral capsid assembly, demonstrating the ability of identical protein dimers to adopt multiple geometries under the same solution conditions. A we…
Chirality Amplification and Chiral Segregation in Liquid Crystals
Matthew J. Deutsch, Robin L. B. Selinger, Paul van der Schoot
Liquid crystal mesophases of achiral molecules are normally achiral, yet in a few materials they spontaneously segregate and form right- and left-handed chiral domains. One mechani…
An Assembly-Line Mechanism for In-Vitro Encapsulation of Fragmented Cargo in Virus-Like Particles
Ayesha Amjad, Irina Tsvetkova, Lena G. Lowry +4
The ability of virus shells to encapsulate a wide range of functional cargoes, especially multiple cargoes - siRNAs, enzymes, and chromophores - has made them an essential tool in…
Impact of the RNA Binding Domain Localization of the Protein Shell on Virus Particle Stability
Mohammadamin Safdari, Siyu Li, Sanaz Panahandeh +2
The encapsulation of polyanions, whether single-stranded RNAs or synthetic polymers, is primarily driven by attractive electrostatic interactions between the positively charged, st…