9 citations · 33 across the 16 of their papers we have counts for
17 papers
In Silico Implementation of Evolutionary Paradigm in Therapy Design: Towards Anti-Cancer Therapy as Darwinian Process
Branislav Brutovsky, Denis Horvath
In here presented in silico study we suggest a way how to implement the evolutionary principles into anti-cancer therapy design. We hypothesize that instead of its ongoing supervis…
A New Conceptual Framework for the Therapy by Optimized Multidimensional Pulses of Therapeutic Activity. The case of Multiple Myeloma Model
Denis Horváth, Branislav Brutovsky
We developed simulation methodology to assess eventual therapeutic efficiency of exogenous multiparametric changes in a four-component cellular system described by the system of or…
Toward understanding of the role of reversibility of phenotypic switching in the evolution of resistance to therapy
Denis Horvath, Branislav Brutovsky
Reversibility of state transitions is intensively studied topic in many scientific disciplines over many years. In cell biology, it plays an important role in epigenetic variation…
Self-organized manifold learning and heuristic charting via adaptive metrics
Denis Horvath, Jozef Ulicny, Branislav Brutovsky
Classical metric and non-metric multidimensional scaling (MDS) variants are widely known manifold learning (ML) methods which enable construction of low dimensional representation…
Towards Inverse Modeling of Intratumoral Heterogeneity
Branislav Brutovsky, Denis Horvath
Development of resistance limits efficiency of present anticancer therapies and preventing it remains big challenge in cancer research. It is accepted, at intuitive level, that the…
Structure of Intratumor Heterogeneity: Is Cancer Hedging Its Bets?
B. Brutovsky, D. Horvath
Development of resistance limits transferability of most anticancer therapies into curative treatment and understanding mechanisms beyond it remains a big challenge. Many high reso…