493 citations · 6.1k across the 85 of their papers we have counts for
36 papers · 1 filter
Flow, dynamics and active fracture in hydraulic multicellular systems
John D. Treado, Arthur Boutillon, Frank Jülicher +1
From interstitial space to luminal cavities, fluid pressure and flow can remodel, reshape and even redefine a biological tissue. Fluids can either govern or react to mechanical int…
Continuous Game of Life: cell emergence and self-organization at the edge of growth
Alexandre Guillet, Frank Jülicher
Conway's Game of Life shows that simple rules can generate a rich diversity of emerging structures. This cellular automaton has been translated to continuous space by Rafler (2011)…
Flow-wave coupling synchronizes oscillations in growing active matter
Lara Koehler, Elissavet Sandaltzopoulou, Frank Jülicher +1
Oscillatory biochemical signals and mechanical forces must coordinate robustly during development, yet the principles governing their mutual coupling remain poorly understood. In s…
Active Loop Extrusion guides DNA-Protein Condensation
Ryota Takaki, Yahor Savich, Jan Brugués +1
The spatial organization of DNA involves DNA loop extrusion and the formation of protein-DNA condensates. While the significance of each process is increasingly recognized, their i…
Length control of long cell protrusions: rulers, timers and transport
Swayamshree Patra, Debashish Chowdhury, Frank Jülicher
A living cell uses long tubular appendages for locomotion and sensory purposes. Hence, assembling and maintaining a protrusion of correct length is crucial for its survival and ove…
Energy and Matter Supply for Active Droplets
Jonathan Bauermann, Christoph A. Weber, Frank Jülicher
Chemically active droplets provide simple models for cell-like systems that can grow and divide. Such active droplet systems are driven away from thermodynamic equilibrium and turn…
Chemical Kinetics and Mass Action in Coexisting Phases
Jonathan Bauermann, Sudarshana Laha, Patrick M. McCall +2
The kinetics of chemical reactions are determined by the law of mass action, which has been successfully applied to homogeneous, dilute mixtures. At non-dilute conditions, interact…
Active T1 transitions in cellular networks
Charlie Duclut, Joris Paijmans, Mandar M. Inamdar +2
In amorphous solids as in tissues, neighbor exchanges can relax local stresses and allow the material to flow. In this paper, we use an anisotropic vertex model to study T1 rearran…
Thermodynamics of Wetting, Prewetting and Surface Phase Transitions with Surface Binding
Xueping Zhao, Giacomo Bartolucci, Alf Honigmann +2
In living cells, protein-rich condensates can wet the cell membrane and surfaces of membrane-bound organelles. Interestingly, many phase-separating proteins also bind to membranes…
Molecular Assembly Lines in Active Droplets
Tyler S. Harmon, Frank Jülicher
Large protein complexes are assembled from protein subunits to form a specific structure. In our theoretic work, we propose that assembly into the correct structure could be reliab…
Hydraulic and electric control of cell spheroids
Charlie Duclut, Jacques Prost, Frank Jülicher
We use a theoretical approach to examine the effect of a radial fluid flow or electric current on the growth and homeostasis of a cell spheroid. Such conditions may be generated by…
Inferring the flow properties of epithelial tissues from their geometry
Marko Popović, Valentin Druelle, Natalie A. Dye +2
Amorphous materials exhibit complex material proprteties with strongly nonlinear behaviors. Below a yield stress they behave as plastic solids, while they start to yield above a cr…
Flagellar length control in biflagellate eukaryotes: time-of-flight, shared pool, train traffic and cooperative phenomena
Swayamshree Patra, Frank Jülicher, Debashish Chowdhury
Flagella of eukaryotic cells are transient long cylindrical protrusions. The proteins needed to form and maintain flagella are synthesized in the cell body and transported to the d…
Liquid phase separation controlled by pH
Omar Adame-Arana, Christoph A. Weber, Vasily Zaburdaev +2
We present a minimal model to study liquid phase separation in a fixed pH ensemble. The model describes a mixture composed of macromolecules that exist in three different charge st…
Dynamic modes of morphogen transport
Daniel Aguilar Hidalgo, Zena Hadjivasilou, Maria Romanova-Michaelides +2
Morphogens are secreted signaling molecules that mediate tissue patterning and growth of embryonic tissues. They are secreted in a localized region and spread through the tissue to…
Fluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies
Charlie Duclut, Niladri Sarkar, Jacques Prost +1
We discuss the physical mechanisms that promote or suppress the nucleation of a fluid-filled lumen inside a cell assembly or a tissue. We discuss lumen formation in a continuum the…
Chemical event chain model of coupled genetic oscillators
David J. Jörg, Luis G. Morelli, Frank Jülicher
We introduce a stochastic model of coupled genetic oscillators in which chains of chemical events involved in gene regulation and expression are represented as sequences of Poisson…
Role of hydrodynamic flows in chemically driven droplet division
Rabea Seyboldt, Frank Jülicher
We study the hydrodynamics and shape changes of chemically active droplets. In non-spherical droplets, surface tension generates hydrodynamic flows that drive liquid droplets into…
Critical Point in Self-Organized Tissue Growth
Daniel Aguilar Hidalgo, Steffen Werner, Ortrud Wartlick +3
We present a theory of pattern formation in growing domains inspired by biological examples of tissue development. Gradients of signaling molecules regulate growth, while growth ch…
Droplet Ripening in Concentration Gradients
Christoph A. Weber, Chiu Fan Lee, Frank Jülicher
Living cells use phase separation and concentration gradients to organize chemical compartments in space. Here, we present a theoretical study of droplet dynamics in gradient syste…
Mechanics of active surfaces
Guillaume Salbreux, Frank Jülicher
We derive a fully covariant theory of the mechanics of active surfaces. This theory provides a framework for the study of active biological or chemical processes at surfaces, such…
Sequential pattern formation governed by signaling gradients
David J. Jörg, Andrew C. Oates, Frank Jülicher
Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing th…
Active dynamics of tissue shear flow
Marko Popović, Amitabha Nandi, Matthias Merkel +4
We present a hydrodynamic theory to describe shear flows in developing epithelial tissues. We introduce hydrodynamic fields corresponding to state properties of constituent cells a…
Growth and Division of Active Droplets: A Model for Protocells
David Zwicker, Rabea Seyboldt, Christoph A. Weber +2
It has been proposed that during the early steps in the origin of life, small droplets could have formed via the segregation of molecules from complex mixtures by phase separation.…